This symposium was organized at the B.M. Birla Science Centre, Hyderabad, India, and provided a platform for frontier physicists to exchange ideas and review the latest work and developments on a variety of interrelated topics. A feature of the symposium, as well as the proceedings, is the B.M. Birla Memorial Lecture by Nobel Laureate Professor Gerard t Hooft. There were participants from the USA, several European countries, Russia and CIS countries, South Africa, Japan, India and elsewhere, of whom some forty scientists presented papers. Spanning a wide range of contemporary issues in fundamental physics from string theory to cosmology, the proceedings present many of these talks and contributions.