Phytochemical Screening and Pharmacological Investigations on Hedychium coronarium

The present study was carried out for phytochemical screening and pharmacological investigations on methanolic extract of rhizomes of Hedychium coronarium (Local name: Dolan Champa, Family: Zingiberaceae). In this study, the possible analgesic and CNS (Central Nervous System) depressant activities of the methanolic rhizome extract of Hedychium coronarium were investigated at the doses of 100 mg/Kg, 200 mg/kg and 400 mg/Kg body weight on mice by oral administration. The analgesic activities were investigated for their central and peripheral pharmacological actions using tail immersion testing and acetic acid-induced writhing testing respectively. Its CNS depressant activity was evaluated by using hole cross and open field tests and the cytotoxic activity was observed using brine shrimp lethality bioassay.