Mechanistic Toxicology: The Molecular Basis of How Chemicals Disrupt Biological Targets

Incorporating recent advances in molecular biology and examining cellular and molecular mechanisms with regard to toxic effects, this second edition features new chapters on types of toxic responses, novel mechanisms derived from systems toxicology, and disruption of cellular signal transduction. Expanded chapters include the disruption of mitochondrial function, mitochondrial outer membrane permeabilization, and selective depletion of mitochondrial DNA. The book links molecular and cellular biology with xenobiotic toxicology and contains new examples and illustrations to supplement material. Additional topics include oxidant stress, apoptotic and necrotic cell death, nuclear-receptor-mediated toxicity, and immune-mediated toxicity.