CURRENT STATUS OF GENE THERAPY IN PERIODONTICS

This book presents a comprehensive analysis of the application of gene therapy in dentistry. Gene therapy offers a paradigm shift by addressing oral diseases at the molecular level, aiming for preventive and regenerative outcomes. This book explores the multifactorial etiology of periodontitis, integrating microbial, environmental, genetic, and immunological components. Multiple disease progression models like the linear, burst, and dysbiosis based are reviewed to elucidate clinical variability. A detailed examination of genetic polymorphisms (eg, IL-1, IL-6, TNF-α) illustrates host susceptibility and pathogenesis. The book also evaluates gene-based therapeutic strategies, including immunomodulation and tissue regeneration, emphasizing the role of mesenchymal stem cells and advanced delivery systems. Ethical considerations and future research directions are discussed, positioning gene therapy as a promising frontier in personalized dental care. This publication aims to contribute meaningfully to dental sciences and biomedical research.