Antiarrhythmic Drugs : Mechanisms of Antiarrhythmic and Proarrhythmic Actions

The past 10 years have seen a remarkable change in the approach to cardiac arrhythmias, from a position of confidence and a feeling of well-being about pharmacological treatment to a situation in which there is now marked uncertainty and general apprehension about the role of antiarrhythmic drugs. Until relatively recently the prevailing concept in antiarrhythmic therapy was that arrhythmias could be controlled by drugs which slowed conduction or suppressed automaticity, goals well served by the sodium channel-blocking drugs and glycosides. Drug re- search was based largely on the development of agents mimicking those already available, but with greater efficacy, fewer side effects or a more favourable phar- macokinetic profile. The CAST trial stands out as a landmark in the evolution of arrhytmia manage- ment; rarely has a single trial had such a profound impact not only on clinical prac- tice, but also on the whole approach of those involved in the research, development and regulation of antiarrhythmic drugs. The results of the CAST trial, designed to redress the shortcomings of earlier trials which had failed to demonstrate the anticipated improvement in mortality post-myocardial infarction with the use of class I agents, are well known. The CAST and CAST II showed an increase in mor- tality associated with the active agent (encainide, flecainide or morizicine) com- pared to placebo treatment. They firmly established the potential danger in the use of class I drugs.