Molecular events related to oxidative and nitrosative stress during brain aging

Doctoral Thesis / Dissertation from the year 2013 in the subject Chemistry - Bio-chemistry, language: English, abstract: This thesis aims at investigating the role of oxidative/nitrosative stress and mitochondrial damage in aging, neurodegeneration and neurotrauma in postmortem human brain samples. The study also aims to carry out proteomic analysis of the human brains from TBI subjects to understand and differentiate the primary and secondary events in TBI. Even at rest, an estimated 20% of the total oxygen uptake by our body is utilized by the brain, which is the most metabolically active organ in the human body. While >95% of the oxygen taken up by the cells is utilized by the mitochondria