Graphs and Genes

This book is written by a mathematician and a theoretical biologist who have arrived at a good mutual understanding and a well worked-out common notation. The reader need hardly be convinced of the necessity of such a mutual understanding, not only for the two investigators, but also for the sciences they represent. Like Molieres hero, geneticists are gradually beginning to understand that, unknowingly, they have been speaking in the language of cybernetics. Mathematicians are unexpec- tedly discovering that many past and present problems and methods of genetics can be naturally formulated in the language of graph theory. In this way a powerful abstract mathematical theory suddenly finds a productive application. Moreover, in its turn, such an application be- gins to "feed" the mathematical theory by presenting it with a number of new problems. The reader may judge for himself the fruitfulness of such mutual interaction. At the same time several important circumstances need to be men- tioned. The formalization and rigorous formulation given here embraces not only the older problems, known by geneticists for many decades (the construction of genetic maps, the analysis of complementation, etc. ), but also comparatively new problems: the construction of partial com- plementation maps, phylogenetic trees of proteins, etc.