Effects of Valsartan and Amlodipine in SHR Rats

Arterial hypertension is a widespread non-communicable disease of the modern world and as such one of the most common tasks of general practitioners. Its progression is associated with functional and structural abnormalities that damage target organs. For these reasons, hypertension is important risk factor for arteriosclerosis, myocardial infarction, heart failure and stroke. Despite extensive research conducted to investigate the mechanisms responsible for its pathogenesis, the exact cause of the appearance of increased blood pressure in most patients remains unknown.The primary aim of this book was to evaluate the therapeutic effects of Valsartan and Amlodipine, applied as monotherapy and combination therapy for treatment of hypertension followed by secondary complications. The effects of the studied drugs were analyzed through their protective action on the heart, aorta, kidneys and the brain in salt replete SHR rats.