Cell Line Development

1. Use of MAR elements to increase the production of recombinant proteins, Cori Gorman, Salina Arope, Mélanie Grandjean, Pierre-Alain Girod, and Nicolas Mermod; 2. Expression Engineering - the IE2 promoter/enhancer from mouse CMV, Markus O. Imhof; 3. Defeating Randomness - Targeted Integration as a Boost for Biotechnology, Gama-Norton, L.; Riemer, P.; Sandhu, U.; Nehlsen, K.; Schucht, R.; Hauser, H. and Wirth D.; 4. Importance of genetic environment for recombinant gene expression, Alan J. Dickson; 5. Expression Vector Engineering for Recombinant Protein Production, Helen Kim, John Laudemann, Jennitte Stevens and Michelle Wu; 6. Cell XpressTM Applications in Development and Characterization of Biopharmaceutical Recombinant Protein Producing Cell Lines, Jennifer R. Cresswell, Nan Lin, Genova A. Richardson and Kevin J. Kayser; 7. Selection Methods for High-Producing Mammalian Cell Lines, S. M. Browne and M. Al-Rubeai; 8. Engineering Mammalian Cells for Recombinant Monoclonal Antibody Production, Sarah L. Davies and David C. James; 9. Engineering Cell Function by RNA Interference, Joseph A. Gredell, Hemant K. Kini, and S. Patrick Walton; 10. Apoptosis and Autophagy Cell Engineering, Chaya Mohan, Yeon-Gu Kim, Gyun Min Lee; 11. Glycoengineering and Modeling of Protein N-Glycosylation, Sandra V. Bennun, Frederick J. Krambeck and Michael J. Betenbaugh; 12. Engineering the Secretory pathway in mammalian cells, Ren-Wang Peng and Martin Fussenegger